Translation Regulation by eIF2α Phosphorylation and mTORC1 Signaling Pathways in Non-Communicable Diseases (NCDs)

NON-COMMUNICABLE DISEASES (NCDs) AND ASSOCIATED RISK FACTORS IN EUROPE

Non‐Communicable Diseases (NCDs) in developing countries: a symposium report

In recent years, non-communicable diseases (NCDs) have globally shown increasing impact on health status in populations with disproportionately higher rates in developing countries. NCDs are the leading cause of mortality worldwide and a serious public health threat to developing countries. Recognizing the importance and urgency of the issue, a one-day symposium was organized on NCDs in Develop...

State model for partly undetected non-communicable diseases (NCDs)

This article proposes an age-structured compartment model for irreversible diseases with a pre-clinical state of undiagnosed cases that precedes the diagnosis. The model is able to cope with mortality rates differing between the pre-clinical and the clinical state (differential mortality). Applicability is tested in a hypothetical disease with realistic incidence and mortality rates.

Regulation of mRNA translation by signaling pathways.

mRNA translation is the most energy consuming process in the cell. In addition, it plays a pivotal role in the control of gene expression and is therefore tightly regulated. In response to various extracellular stimuli and intracellular cues, signaling pathways induce quantitative and qualitative changes in mRNA translation by modulating the phosphorylation status and thus the activity of compo...

Alcohol and non-communicable diseases (NCDs): time for a serious international public health effort.

Each year, in connection with the opening of the General Assembly sessions, the United Nations holds a special session on an agreed-upon topic. In 2011, the topic is non-communicable diseases (NCDs), arguing for their inclusion in the Millennium Development Goals, with the primary goal of emphasizing the importance of addressing such diseases in order to reduce the global burden of illness, not...